Sheth, A. R. ; Joseph, R. ; Maitra, A. (1987) Thyroid releasing hormone inhibits testosterone metabolism by rat prostate in vitro Andrologia, 19 (2). pp. 188-192. ISSN 0303-4569
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1439-...
Related URL: http://dx.doi.org/10.1111/j.1439-0272.1987.tb01883.x
Abstract
A method involving thin layer chromatography (TLC) was developed to assess 5 α-DHT-réductase activity in rat ventral prostate, in terms of the amount of testosterone metabolised to its main 5 α-reduced compound, dihydrotestosterone (DHT). Using this method an in vitro study was carried out to determine 5 α-DHT reductase activity in the rat ventral prostate as modulated by thyroid releasing hormone (TRH). The study revealed a decrease in the enzmye activity with increasing doses of TRH, as shown by a decrease in the extent of reduction of testosterone to DHT. The ratios of the counts for DHT and testosterone however did not show any dose related effect.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons. |
| Keywords: | Testosterone Metabolism; TRH; Prostate; TRH |
| ID Code: | 77998 |
| Deposited On: | 16 Jan 2012 12:52 |
| Last Modified: | 16 Jan 2012 12:52 |
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