Premature ovarian failure

Abstract

Twelve cases of premature ovarian failure (POF) are described. The clinical, hormonal, histopathologic and cytogenetic studies of each patient have been presented. The scope and the limitations of laparoscopic ovarian biopsy are discussed, as is the importance of radioimmunoassay of follicle-stimulating and luteinizing hormones (FSH/LH) in comparison to ovarian biopsy for the diagnosis of premature ovarian failure. A plea is made for the early diagnosis of POF so that these young women can be spared the expensive and time-consuming treatment for the associated problem of infertility. PIP: The clinical, hormonal, cytogenetic, and ovarian histopathologic findings in 12 cases of premature ovarian failure are described. The scope and limitations of laparoscopic ovarian biopsy are discussed, as is the importance of radioimmunoassay of follicle stimulating and luteinizing hormones in comparison to ovarian biopsy for the diagnosis of premature ovarian failure. It is concluded that serum gonadotropin estimations and laparoscopic ovarian biopsies are complementary tools for the diagnosis of premature ovarian failure, and that 1 cannot replace the other for a final diagnosis. However, when facilities for radioimmunoassay for gonadotropins are not available, laparoscopic examination of ovaries and ovarian biopsies can alert the gynecologist to the diagnosis of premature ovarian failure. In the absence of a clinical response to clomid, the diagnosis could be confirmed. Early diagnosis can prevent the expense and time-consuming treatment for the associated problem of infertility.