Effect of Prostaglandins A-1, E-2 and F-2a on blood plasma levels of testosterone, LH and FSH in male rats

Abstract

The effect of prostaglandins A-1, E-2 and F-2a on testosterone, LH and FSH levels in the blood plasma of male rats The effect of prostaglandins A-1, E-2 and F-2a, the rats were administered at a dose of 150 U / rat intraperitonel for 10 days was investigated. A significant increase in testicular weight was observed only in the group who had been treated with prostaglandin E-2. The content of the testis of ascorbic acid was significantly reduced following treatment with all prostaglandins. Treatment with prostaglandin E-2 provoked a significant decrease in the content of cholesterol in the testes hervir, while no changes of the same compound and prostatic acid phosphatase activity in each of the groups treated with prostaglandins were observed. Testosterone levels were measured in blood plasma both by prostaglandin E-2 and prostaglandin-2a greatly reduced, while there were no changes in plasma LH levels in all groups. Only in rats that were treated with prostaglandin A-1, the concentration of FSH increased significantly. The results suggest that 1.there is a direct effect of prostaglandins, especially prostaglandin E-2, are on the testicular weight. Prostaglandin E-2 increases the testicular weight may in that it prevents the degeneration of spermatids. 2 Prostaglandin E-2 directly acts on the testes, the content of the testis of ascorbic acid decreased, stimulates the conversion of cholesterol to pregnenolone, but suppresses the conversion of testosterone into the latter.