Dehydrolysine containing analogues of tuftsin: synthesis and bioactivity

Gupta, Sunanda D. ; Jain, Ratanmani ; Chauhan, Virender S. (1994) Dehydrolysine containing analogues of tuftsin: synthesis and bioactivity Bioorganic & Medicinal Chemistry Letters, 4 (7). pp. 941-944. ISSN 0960-894X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0960-894X(01)80268-7

Abstract

Two analogues of tuftsin containing α,β-dehydrolysine. Thr-Δ-Lys-Pro-Arg (1) and Leu-ΔLys-Pro-Arg (2) have been synthesised. Presence of ΔLys moiety has been confirmed by 1H NMR and aminoacid analysis. Analogue (1) and (2) have been checked for their phagocytic activity.

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