Bajpai, K. ; Singh, V. K. ; Dhawan, V. C. ; Haq, W. ; Mathur, K. B. ; Agarwal, S. S. (1997) Immunomodulation by two potent analogs of met-enkephalin Immunopharmacology, 35 (3). pp. 213-220. ISSN 0162-3109
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01623...
Related URL: http://dx.doi.org/10.1016/S0162-3109(96)00147-6
Abstract
Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and its more stable analogs, Tyr-D-Ala-Gly-MePhe-Met-NHC3H7-iso (1) and Tyr-D-Ala-Gly-MePhe-Gly-NHC3H7-iso (2) significantly enhanced human T-cell proliferation in vitro after 5 days of incubation in the absence of mitogen. The activity was completely inhibited by naloxone, an opioid antagonist. These peptides significantly enhanced human active T-cell rosette (CD2R) also on in vitro treatment. Furthermore, these analogs stimulated interleukin-2 production by human peripheral blood mononuclear cells in vitro which was completely inhibited by naloxone. These observations suggest that human T-cells bear receptors for Met-enkephalin on their surface. Such findings may provide a link between the central nervous system and the immune system.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Enkephalin; Immunomodulator; T-cell Proliferation; Interleukin-2; T-cell Rosette |
| ID Code: | 77 |
| Deposited On: | 16 Sep 2010 10:47 |
| Last Modified: | 12 May 2011 03:49 |
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