Some statistical models, methods, applications in genetics

Abstract

Some statistical models and methods used in genetical studies of populations are described. In particular, estimation procedures pertaining to parameters of models used for measuring genetic structures of contemporary populations, within and between population genetic diversities and population phylogenies are discussed. A second section of this paper describes models and procedures pertaining to genetical studies in families. Models for estimating genetic and environmental components in the determination of a quantitative character are described. An application to family data on blood pressures is presented. A newly developed multi locus epistatic model is described, likelihood of non-randomly sampled family data is derived and an application to understanding the genetics of a pigmentary disorder (vitiligo) is presented.