Brown, G. E. ; Lebleu, B. ; Kawakita, M. ; Shaila, S. ; Sen, G. C. ; Lengyel, P. (1976) Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: dependence on double-stranded RNA Biochemical and Biophysical Research Communications, 69 (1). pp. 114-122. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0006-291X(76)80280-X
Abstract
Reovirus messenger RNAs are degraded faster in crude extracts (S30) from mouse Ehrlich ascites tumor cells which have been treated with either a partially purified interferon preparation or the interferon inducer poly(I).poly(C) than in corresponding extracts from untreated cells. The faster degradation appears to be a consequence of endonuclease action. The endonuclease activity invitro depends on the presence of double-stranded reo-virus RNA in the reaction mixture.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 76599 |
| Deposited On: | 04 Jan 2012 12:15 |
| Last Modified: | 04 Jan 2012 12:15 |
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