Seayad, A. ; Jayasree, S. ; Chaudhari, R. V. (1999) Highly efficient catalyst system for the synthesis of 2-arylpropionic acids by carbonylation Catalysis Letters, 61 (1-2). pp. 99-103. ISSN 1011-372X
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Official URL: http://www.springerlink.com/content/h00544w7h6m248...
Related URL: http://dx.doi.org/10.1023/A:1019064603994
Abstract
Carbonylation of 1-(4-isobutylphenyl)ethanol has been studied using a homogeneous catalyst system consisting of PdCl2(PPh3)2/ TsOH/ LiCl. Higher reaction rates with TOF up to 1200 h-1 and ibuprofen selectivity >95% have been achieved at 388 K under a CO partial pressure of 5.4 MPa. The reaction proceeds through the formation of 4-isobutylstyrene and 1-(4-isobutylphenyl)ethyl chloride as intermediates. The same catalyst system is shown to be effective for carbonylation of various a-arylethanols, vinyl aromatics and corresponding chloro derivatives.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer-Verlag. |
| Keywords: | Carbonylation; 1‐(4‐Isobutylphenyl)ethanol; Ibuprofen; Naproxen; Styrene; Palladium; 2‐Arylpropionic Acids |
| ID Code: | 7636 |
| Deposited On: | 25 Oct 2010 10:58 |
| Last Modified: | 30 May 2011 04:08 |
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