Synthesis of p-aminophenol by catalytic hydrogenation of nitrobenzene

Rode, C. V. ; Vaidy, M. J. ; Chaudhari, R. V. (1999) Synthesis of p-aminophenol by catalytic hydrogenation of nitrobenzene Organic Process Research & Development, 3 (6). pp. 465-470. ISSN 1083-6160

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The present work describes the preparation of p-aminophenol via single-step catalytic hydrogenation of nitrobenzene in acid medium. A conventional method of synthesis of p-aminophenol is a two-step reaction involving iron-acid reduction of p-nitrophenol. This method causes serious effluent disposal problems due to the stoichiometric use of iron-acid, which leads to the formation of Fe-FeO sludge (≅ 1.2 kg/kg of product) in the process, which cannot be recycled. The single-step hydrogenation of nitrobenzene was carried out using platinum catalyst, and the process conditions were optimized. Complete conversion of nitrobenzene was achieved with selectivity to p-aminophenol as high as 75% under the best set of conditions. Furthermore, the catalyst can be easily recovered and efficiently recycled giving the TON as high as 1.38 × 10.5 This paper presents studies on the effect of various process parameters such as temperature, hydrogen pressure, and substrate and acid concentration on the rate of reaction and selectivity to p-aminophenol.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:7576
Deposited On:25 Oct 2010 11:07
Last Modified:30 May 2011 04:10

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