Vasanthakumar, Ganga Ramu ; Bhor, Vikrant M. ; Surolia, Avadhesha (2007) Hydrolysis of cyclic ureas under microwave irradiation: synthesis and characterization of 7, 8-diaminopelargonic acid Synthetic Communications, 37 (16). pp. 2633-2639. ISSN 0039-7911
Full text not available from this repository.
Official URL: http://www.tandfonline.com/doi/abs/10.1080/0039791...
Related URL: http://dx.doi.org/10.1080/00397910701464951
Abstract
A simple and efficient method for the synthesis of 7,8-diaminopelargonic acid, a key intermediate in the biotin biosynthesis pathway, is reported. The d-desthiobiotin powder was dissolved in concentrated hydrochloric acid, and the solution was exposed to microwave radiation of 2.45 GHz for varying lengths of time ranging from 60 s to 2 min. The product thus obtained was characterized by spectroscopic techniques and confirmed through bioassay. Further, the protocol was extended to the synthesis of several diamines from their corresponding cyclic ureas. The results show that the method is generally applicable and not only accelerates the hydrolysis reaction but also offers excellent yields.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor and Francis Group. |
| Keywords: | Acid Hydrolysis; Cyclic Urea; D-desthiobiotin; 7,8-diaminopelargonic Acid; Microwave Irradiation |
| ID Code: | 75559 |
| Deposited On: | 24 Dec 2011 11:46 |
| Last Modified: | 24 Dec 2011 11:46 |
Repository Staff Only: item control page
