Parnaik, Veena K. ; Chaturvedi, Pankaj ; Muralikrishna, Bh. (2011) Lamins, laminopathies and disease mechanisms: possible role for proteasomal degradation of key regulatory proteins Journal of Biosciences, 36 (3). pp. 471-479. ISSN 0250-5991
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Official URL: http://www.ias.ac.in/jbiosci/aug2011/471.pdf
Related URL: http://dx.doi.org/10.1007/s12038-011-9085-2
Abstract
Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Academy of Sciences. |
Keywords: | Dna Repair; Heterochromatin; Lamin; Nuclear Envelope; Proteasome; Ubiquitin Ligases |
ID Code: | 75328 |
Deposited On: | 22 Dec 2011 13:07 |
Last Modified: | 18 May 2016 19:23 |
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