Mohankrtshnan, P. ; Hutchins, L. ; Nauke, S. ; Sprigg, J. ; Cardwell, D. ; Wllltamson, M. R. ; Komoroski, R. A. ; Jagannathan', N. R. (1999) Metabolism of 5-fluorouracil in human liver: An in vivo 19 F NMR study Current Science, 76 (5). pp. 677-680. ISSN 0011-3891
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Abstract
In vivo fluorine 19 nuclear magnetic resonance 19F NMR) spectroscopy was used to study the metabolism and pharmacokinetics of 5-fluorouracil (5-FU) in human liver. Nine patients received 5-FU, and additional chemotherapeutic agents (methotrexate, leucovorin, or levarnisole) either prophylac tically after breast cancer surgery or for colorectal cancer. The time constant for the disappearance of 5-FU from the liver in vivo varied from S to 17 min, while the time constant for the appearance of α-fluoro-β-alanine (the major catabolite of 5-FU) varied from 7 to 86 min. The modulators of 5-FU metabolism did not appear to affect the time constant for the disappearance of 5-FU from the liver or for the appearance of α-fluoro-β-alanine. Results obtained indicate that the pharmacokineties of S-FU and α-fluoro-β-alanine may vary substantially at different times in a given individual.
Item Type: | Article |
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Source: | Copyright of this article belongs to Current Science Association. |
ID Code: | 74381 |
Deposited On: | 12 Dec 2011 04:21 |
Last Modified: | 18 May 2016 18:49 |
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