Jagannathan, N. R. ; Desai, N. G. ; Raghunathan, P. (1996) Brain metabolite changes in alcoholism: An in vivo proton magnetic resonance spectroscopy (MRS) study Magnetic Resonance Imaging, 14 (5). pp. 553-557. ISSN 0730-725X
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0730-725X(96)00048-3
Abstract
Image-guided, single voxel, localized proton magnetic resonance (MR) spectroscopy was performed to assess the brain metabolite changes in 10 (n = 10) alcoholic patients in the frontal lobe, cerebellum, and thalamus regions. The spectra obtained were characterized by a reduced N-acetyl-aspartate (NAA) to choline (Cho) (p < .01) and NAA to total creatine (Cr + PCr) (p < .01) ratios relative to age-matched (n = 27) controls. These decreased ratios correspond to depleted concentration of the metabolite levels such as NAA and Cho. Reduction of NAA is consistent with the neuronal loss while reduction in Cho suggests significant changes in the membrane lipids of alcoholics.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Magnetic Resonance Spectroscopy (MRS); Alcoholism; NAA/(Cr+PCr); NAA/Cho; Brain Metabolite Changes |
| ID Code: | 74315 |
| Deposited On: | 31 Dec 2011 12:12 |
| Last Modified: | 31 Dec 2011 12:12 |
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