Sharma, R. P. ; Chopra, V. L. (1975) Innate metabolic differences and mutagen sensitivity of Drosophila melanogaster: I. Radiosensitivity of hyperkinetic mutant Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 30 (1). pp. 77-82. ISSN 1386-1964
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0027-5107(75)90255-9
Abstract
The sensitivity to gamma-rays of a hyperkinetic mutant (HK1), characterized by high metabolic activity, has been studied and compared with gamma-ray sensitivity of the wild-type Oregon-K. Radiation damage, as measured by the frequency of induced dominant lethals (DL) and sex-linked recessive lethals (SLRL), was more in HK1 as compared with Or-K. The maximal sensitivity differences for these parameters were observed in the first brood. Translocations, on the contrary, were in general fewer in the HK1 compared with Or-K. These results have been interpreted in terms of reduced repair of mutational lesions in the energy-stressed cells of HK1.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 74059 |
| Deposited On: | 08 Dec 2011 12:15 |
| Last Modified: | 13 Jul 2012 14:45 |
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