Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K. ; Calacal, Gayvelline C. ; Chaurasia, Amit ; Chen, Chien-Hsiun ; Chen, Jieming ; Chen, Yuan-Tsong ; . . . ; Majumder, P. P.; . . . (The HUGO Pan-Asian SNP Consortium) (2009) Mapping human genetic diversity in Asia Science, 326 (5959). pp. 1541-1545. ISSN 0036-8075
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Official URL: http://www.sciencemag.org/content/326/5959/1541.ab...
Related URL: http://dx.doi.org/10.1126/science.1177074
Abstract
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association for the Advancement of Science. |
| ID Code: | 73352 |
| Deposited On: | 03 Dec 2011 12:17 |
| Last Modified: | 12 Feb 2013 11:31 |
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