Deka, R. ; Chakravarti, A. ; Surti, U. ; Hauselman, E. ; Reefer, J. ; Majumder, P. P. ; Ferrell, R. E. (1990) Genetics and biology of human ovarian teratomas. II. Molecular analysis of origin of nondisjunction and gene-centromere mapping of chromosome I markers The American Journal of Human Genetics, 47 (4). pp. 644-655. ISSN 0002-9297
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Abstract
Chromosomal heteromorphisms and DNA polymorphisms have been utilized to identify the mechanisms that lead to formation of human ovarian teratomas and to construct a gene-centromere map of chromosome 1 by using those teratomas that arise by meiotic nondisjunction. Of 61 genetically informative ovarian teratomas, 21.3% arose by nondisjunction at meiosis I, and 39.3% arose by meiosis II nondisjunction. Eight polymorphic marker loci on chromosome 1p and one marker on 1q were used to estimate a gene-centromere map. The results show clear linkage of the most proximal 1p marker (NRAS) and the most proximal 1q marker (D1S61) to the centromere at a distance of 14 cm and 20 cm, respectively. Estimated gene-centromere distances suggest that, while recombination occurs normally in ovarian teratomas arising by meiosis II errors, ovarian teratomas arising by meiosis I nondisjunction have altered patterns of recombination. Furthermore, the estimated map demonstrates clear evidence of chiasma interference. Our results suggest that ovarian teratomas can provide a rapid method for mapping genes relative to the centromere.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Society of Human Genetics. |
ID Code: | 73274 |
Deposited On: | 03 Dec 2011 12:09 |
Last Modified: | 03 Dec 2011 12:09 |
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