Chattopadhyay, Amitabha ; Komath, Sneha Sudha ; Raman, B. (1992) Aggregation of lasalocid A in membranes: a fluorescence study Biochimica et Biophysica Acta (BBA) - Biomembranes, 1104 (1). pp. 147-150. ISSN 0005-2736
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000527...
Related URL: http://dx.doi.org/10.1016/0005-2736(92)90143-A
Abstract
The aggregation behavior of the carboxylic ionophore, lasalocid A, has been studied in egg phosphatidylcholine vesicles by monitoring the intrinsic fluorescence of lasalocid A. Self quenching of lasalocid A fluorescence in vesicles of egg phosphatidylcholine suggests aggregation of lasalocid A. When aggregated lasalocid A is treated with increasing concentrations of lipid, there is an increase in fluorescence due to gradual reduction of self quenching on lateral dilution. This confirms the presence of loosely held non-covalent aggregates of lasalocid A in the membrane. This result is relevant in elucidating the molecular mechanism of cation transport by lasalocid A across membranes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Lasalocid A; Aggregation; Ionophore; Model Membrane; Fluorescence Self Quenching |
| ID Code: | 7317 |
| Deposited On: | 25 Oct 2010 11:51 |
| Last Modified: | 25 Oct 2010 11:51 |
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