Flip angle dependence in two-dimensional multiple quantum coherence NMR spectroscopy

Abstract

The multiple-quantum pathway description developed earlier for two-dimensional single-quatum correlation spectroscopy (COSY), is generalized and applied to the two-dimensional multiple-quantum (2D MOT) spectroscopy. The connectivity classes of COSY are also generalized to MQT spectroscopy. The pathway description allows a straightforward method of computation of the flip angle dependence of the intensity of various peaks in two-dimensional correlation spectroscopy. It is shown that a variation of flip angle allows distinction between various classes and types of transitions, as well as optimization of experiment for selective detection of certain classes of peaks in 2D spectroscopy.