Free radical injury in Human Renal Allograft rejection

Abstract

Plasma and renal tissue levels of lipid peroxide and plasma vitamin E were estimated as measures of free radical injury in five renal allograft recipients with untreated and four with unsuccessfully treated acute cellular rejection and compared with 11 control patients with minimal change disease. Plasma lipid peroxide was significantly higher in patients studied before antirejection therapy (13.2 ± 3.5 nmol/ml; P < 0.01) as well as in those after unsuccessful antirejection treatment (11.7 ± 0.7 nmol/ml; P < 0.01), compared to controls (5.7 ± 2.8 nmol/ml). Levels of plasma vitamin E and renal tissue lipid peroxide were similar in both groups, however the latter was significantly raised in patients evaluated prior to antirejection therapy than in those after unsuccessful antirejection therapy (5.1 ± 1.7 and 3.0 ± 0.8 nmol/mg protein; P < 0.05). These findings suggest possible free radical mediated injury during renal allograft rejection.