Ray, Sutapa ; Majumder, Hemanta K. ; Chakravarty, Ajit K. ; Mukhopadhyay, Sibabrata ; Gil, Roberto R. ; Cordell, Geoffrey A. (1996) Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani Journal of Natural Products, 59 (1). pp. 27-29. ISSN 0163-3864
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Official URL: http://pubs.acs.org/doi/abs/10.1021/np960018g?prev...
Related URL: http://dx.doi.org/10.1021/np960018g
Abstract
A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 72044 |
| Deposited On: | 28 Nov 2011 05:30 |
| Last Modified: | 28 Nov 2011 05:30 |
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