Sundar, Shyam ; Mehta, Himanshu ; Suresh, A. V. ; Singh, Shri P. ; Madhukar, Rai ; Murray, Henry W. (2004) Amphotericin B treatment for Indian visceral leishmaniasis: Conventional versus lipid formulations Clinical Infectious Diseases, 38 (3). pp. 377-383. ISSN 1058-4838
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Official URL: http://cid.oxfordjournals.org/content/38/3/377.abs...
Related URL: http://dx.doi.org/10.1086/380971
Abstract
In Bihar, India, where visceral leishmaniasis is hyperendemic, amphotericin B deoxycholate is now first-line parenteral treatment. To test the efficacy of amphotericin B deoxycholate versus that of its lipid formulations, Indian patients were randomized to receive treatment with amphotericin B deoxycholate (1 mg/kg on alternate days for 30 days; n = 51), liposomal amphotericin B (2 mg/kg per day for 5 days; n = 51), or amphotericin B lipid complex (2 mg/kg per day for 5 days; n = 51). Infusion-associated reactions were frequent and persistent in subjects treated with amphotericin B deoxycholate. The illness of 3 patients failed to respond to treatment, and 5 patients experienced relapse. Final cure rates were similar. Estimated total treatment costs for a 25-kg patient - $417 for amphotericin B deoxycholate, $872 for liposomal amphotericin B, and $947 for amphotericin B lipid complex - differed as a result of drug cost. Substantial reductions (∼60%) in the price of liposomal amphotericin B and amphotericin B lipid complex would make treatment costs comparable to that of amphotericin B deoxycholate, permitting administration of short-course regimens in India.
Item Type: | Article |
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Source: | Copyright of this article belongs to University of Chicago Press. |
ID Code: | 71757 |
Deposited On: | 28 Nov 2011 04:36 |
Last Modified: | 28 Nov 2011 04:36 |
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