Zhao, He ; Zhang, Xiaoyan ; Hodgetts, Kevin ; Thurkauf, Andrew ; Hammer, Jack ; Chandrasekhar, Jayaraman ; Kieltyka, Andrzej ; Brodbeck, Robbin ; Rachwal, Stanislaw ; Primus, Renee ; Manly, Charles (2003) Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: A novel series of mixed dopamine D2/D4 receptor antagonist Bioorganic & Medicinal Chemistry Letters, 13 (4). pp. 701-704. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/S0960-894X(02)01056-9
Abstract
5-Piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. This series featured a rigid tricyclic ring system as an important pharmacophore core structure for high binding affinity. Molecular modeling studies are also described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 7164 |
| Deposited On: | 25 Oct 2010 12:26 |
| Last Modified: | 04 Feb 2011 05:41 |
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