Sundar, Shyam ; Kumar, Kailash ; Chakravarty, Jaya ; Agrawal, Dipti ; Agrawal, Shrinkhla ; Chhabra, Amit ; Singh, Vikram (2006) Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine Transactions of the Royal Society of Tropical Medicine and Hygiene, 100 (7). pp. 698-700. ISSN 0035-9203
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.trstmh.2005.09.015
Abstract
We report the case of a patient with Indian post-kala-azar dermal leishmaniasis (PKDL) who failed to show any response to 2 months' treatment with sodium stibogluconate. Six months later he was treated with oral miltefosine on a compassionate basis as an off-label indication. Miltefosine was given 100mg daily in divided doses for an initial 8 weeks. Due to insufficient response, the treatment was extended up to a total of 12 weeks. The patient showed an excellent response to treatment, and after 12 months of follow-up there was complete healing of all cutaneous lesions. Oral miltefosine appears to be an important alternative for the treatment of PKDL in India and confirmatory studies in controlled clinical trials are needed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Post-kala-azar Dermal Leishmaniasis; PKDL; Miltefosine; Sodium Stibogluconate; India |
| ID Code: | 71382 |
| Deposited On: | 25 Nov 2011 07:25 |
| Last Modified: | 25 Nov 2011 07:25 |
Repository Staff Only: item control page
