Kothari, Hema ; Kumar, Pranav ; Sundar, Shyam ; Singh, Neeloo (2007) Possibility of membrane modification as a mechanism of antimony resistance in Leishmania donovani Parasitology International, 56 (1). pp. 77-80. ISSN 1383-5769
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.parint.2006.10.005
Abstract
Resistance to antimonials has become a clinical threat in the treatment of visceral leishmaniasis (VL). Unravelling the resistance mechanism needs attention to circumvent the problem of drug resistance. In one of the resistant isolates, we earlier identified a gene (PG1) implicated in antimony resistance whose localization in the present study was confirmed on the pellicular plasma membrane of the parasite thereby indicating towards membrane modification as a mechanism of resistance in this resistant isolate.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Leishmania; Visceral leishmaniasis (VL); Clinical isolates; Drug resistance |
| ID Code: | 71381 |
| Deposited On: | 25 Nov 2011 07:29 |
| Last Modified: | 25 Nov 2011 07:29 |
Repository Staff Only: item control page
