Sundar, Shyam ; Sinha, Prabhat Kumar ; Verma, Deepak K. ; Kumar, Nawin ; Alam, Shahnawaj ; Pandey, Krishna ; Kumari, Poonam ; Ravidas, Vidyanand ; Chakravarty, Jaya ; Verma, Neena ; Berman, Jonathan ; Ghalib, Hashim ; Arana, Byron (2011) Ambisome plus miltefosine for Indian patients with kala-azar Transactions of the Royal Society of Tropical Medicine and Hygiene, 105 (2). pp. 115-117. ISSN 0035-9203
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.trstmh.2010.10.008
Abstract
The combination of one intravenous administration of 5mg/kg Ambisome and oral administration of miltefosine, 2.5mg/kg/day for 14 days, was evaluated in 135 Indian patients with kala-azar. The Intent-to-Treat cure rate at 6 months was 124 of the 135 enrolled patients (91.9%: 95% CI=86-96%), and the per protocol cure rate was 124 of 127 evaluable patients (97.6%: 95% CI=93-100%). Side effects could be attributed to each drug separately: fevers, rigors and back pain due to Ambisome; gastrointestinal side effects due to miltefosine. This combination is attractive for reasons of efficacy, tolerance, and feasibility of administration, although the gastrointestinal side effects of miltefosine require medical vigilance.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Ambisome; Miltefosine; Combination Therapy; Kala-azar; Visceral Leishmaniasis; Efficacy |
| ID Code: | 71365 |
| Deposited On: | 25 Nov 2011 12:54 |
| Last Modified: | 25 Nov 2011 12:54 |
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