Gautam, Shalini ; Kumar, Rajiv ; Maurya, Radheshyam ; Nylén, Susanne ; Ansari, Nasim ; Rai, Madhukar ; Sundar, Shyam ; Sacks, David (2011) IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis Journal of Infectious Diseases, 204 (7). pp. 1134-1137. ISSN 0022-1899
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Official URL: http://jid.oxfordjournals.org/content/204/7/1134.a...
Related URL: http://dx.doi.org/10.1093/infdis/jir461
Abstract
The mechanisms underlying the failure to contain the growth of Leishmania parasites in human visceral leishmaniasis (VL) are not understood. L donovani amastigotes were quantified in cultured splenic aspirate cells to assess the function of IL-10 in lesional tissue ex vivo. In 67 patients with active VL, IL-10 neutralization promoted parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change. The splenic cells secreted increased levels of both tumor necrosis factor α (TNFα) and interferon γ (IFNγ) under IL-10-neutralizing conditions. These findings provide direct support for targeting IL-10 as an approach to therapy in human VL.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to University of Chicago Press. |
| ID Code: | 71291 |
| Deposited On: | 25 Nov 2011 12:53 |
| Last Modified: | 25 Nov 2011 12:53 |
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