Srivastava, Pankaj ; Prajapati, Vijay Kumar ; Rai, Madhukar ; Sundar, Shyam (2011) Unusual case of resistance to amphotericin B in visceral Leishmaniasis in a region in India where Leishmaniasis is not endemic Journal of Clinical Microbiology, 49 (8). pp. 3088-3091. ISSN 0095-1137
Full text not available from this repository.
Official URL: http://jcm.asm.org/content/49/8/3088.abstract
Related URL: http://dx.doi.org/10.1128/JCM.00173-11
Abstract
The case of a patient with visceral leishmaniasis showing inadequate response to amphotericin B from a region where leishmaniasis is not endemic is reported, with the Leishmania donovani isolate showing increased tolerance to amphotericin B in vivo. Four single nucleotide polymorphisms (SNPs) detected in the cysteine proteinase B gene resulted in changes to the deduced amino acid sequence: valine→alanine and arginine→leucine. Overexpression and underexpression of proteins were observed in the 65- to 80-kDa range and at 20 kDa, respectively.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| ID Code: | 71286 |
| Deposited On: | 25 Nov 2011 12:55 |
| Last Modified: | 25 Nov 2011 12:55 |
Repository Staff Only: item control page
