The structures of some acylcytosines

Abstract

A number of new acyl derivatives of cytosine and 3-methylcytosines are described. Acylation normally yields N⁴- monoacyl compounds which, in hot 80% acetic acid, yield large amounts of uracil derivatives. Exceptionally, benzoyl chloride can also yield a 1 : N⁴- dibenzoate from 3-methylcytosine and a tribenzoate from cytosine. Similarly, benzoylation of cytidine yields, according to conditions, either a tetrabenzoyl or pentabenzoyl derivative.