Das, Shankar Prasad ; Sinha, Pratima (2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging Biochemical and Biophysical Research Communications, 337 (1). pp. 167-172. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2005.09.034
Abstract
We show that the budding yeast protein Chl1p, required for sister-chromatid cohesion, also modulates transcriptional silencing at HMR and telomeres. The absence of this protein results in increased silencing at HMR and, conversely, in decreased silencing at the telomere. The regulation of silencing by Chl1p at these two loci is dependent on the presence of Sir proteins. Chl1p also acts synergistically with Sir2p to suppress rDNA recombination. In the absence of this protein, yeast cells exhibit reduced life span and hypersensitivity to heat stress. These observations suggest a role of Chl1p in regulating chromatin structure.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Chl1p; Yeast; Transcriptional Silencing; Sister-chromatid cohesion; rDNA Recombination; Sir Proteins; Heat Shock; Life Span; Aging |
| ID Code: | 70445 |
| Deposited On: | 16 Nov 2011 11:25 |
| Last Modified: | 16 Nov 2011 11:25 |
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