Mechanism localisation and control of restriction cleavage of phage T4 and λ chromosomes in vivo

K., Dharmalingam ; Edward B, Goldberg (1976) Mechanism localisation and control of restriction cleavage of phage T4 and λ chromosomes in vivo Nature, 260 (5550). pp. 406-410. ISSN 0028-0836

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Official URL: http://www.nature.com/nature/journal/v260/n5550/ab...

Related URL: http://dx.doi.org/10.1038/260406a0

Abstract

The primary action of restriction endonuclease, cleaving infecting DNA, has been demonstrated in vivo. This primary cleavage is followed rapidly by hydrolysis of the cleaved DNA at its newly exposed termini. Infecting viruses can inactivate cytoplasmic and membrane restriction endonucleases to prevent cleavage of unmodified DNA replicas.

Item Type:Article
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ID Code:70410
Deposited On:17 Nov 2011 03:42
Last Modified:17 Nov 2011 03:42

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