Synthetic Studies toward potent cytotoxic agents amphidinolides: synthesis of the C1-C6 and C9-C17 moieties of amphidinolides O and P

Chakraborty, T. K. ; Das, Sanjib (2000) Synthetic Studies toward potent cytotoxic agents amphidinolides: synthesis of the C1-C6 and C9-C17 moieties of amphidinolides O and P Chemistry Letters, 29 (1). p. 80. ISSN 0366-7022

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Official URL: http://www.jstage.jst.go.jp/article/cl/29/1/29_80/...

Related URL: http://dx.doi.org/10.1246/cl.2000.80

Abstract

Stereoselective synthesis of the (4R)-C1-C6 and (14R, 15R)-C9-C17 segments, 4 and 5 respectively, of amphidinolides O and P have been achieved starting from a common chiral precursor 6 which was obtained by radical-mediated opening of a trisubstituted epoxy alcohol using Cp2TiCl-cyclohexa-1,4-diene.

Item Type:Article
Source:Copyright of this article belongs to Chemical Society of Japan.
ID Code:69589
Deposited On:14 Nov 2011 03:52
Last Modified:14 Nov 2011 03:52

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