Singh, M. ; Balamurugan, A. ; Katoch, K. ; Sharma, S. K. ; Mehra, N. K. (2007) Immunogenetics of mycobacterial infections in the North Indian population Tissue Antigens, 69 (Suppl. s1). pp. 228-230. ISSN 0001-2815
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...
Related URL: http://dx.doi.org/10.1111/j.1399-0039.2006.77311.x
Abstract
Several lines of evidence highlight the genetic basis of risk to develop mycobacterial diseases. Human leukocyte antigen (HLA)-DR2 alleles (DRB1∗1501 and DRB1∗1502) have been found to be strongly associated with mycobacterial disease, especially the more severe forms such as lepromatous leprosy and multidrug-resistant pulmonary tuberculosis. In this study, DNA-based high-resolution typing techniques of polymerase chain reaction-sequence-specific oligonucleotide probe were used to determine the distribution of HLA-DR/DQ alleles in patients with leprosy and pulmonary tuberculosis. Analysis of different DR2 subtypes based on valine/glycine dimorphism at codon β86 in pocket 1 of HLA-DR showed an inverse relationship of DR2 alleles with V/G as the severity of disease increased both in leprosy and in pulmonary tuberculosis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Human Leukocyte Antigen (HLA); Polymerase Chain Reaction (PCR); Sequence Specific Oligonucleotide Probe (SSOP) |
| ID Code: | 69368 |
| Deposited On: | 10 Nov 2011 10:20 |
| Last Modified: | 10 Nov 2011 10:20 |
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