Sharma, S. ; Nagarkatti, R. ; B-Rao, C. ; Niphadkar, P. V. ; Vijayan, V. ; Sharma, S. K. ; Ghosh, B. (2004) A_16_C haplotype in the FcεRIβ gene confers a higher risk for atopic asthma in the Indian population Clinical Genetics, 66 (5). pp. 417-425. ISSN 0009-9163
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...
Related URL: http://dx.doi.org/10.1111/j.1399-0004.2004.00333.x
Abstract
We conducted a case-control study aimed at identifying polymorphisms and haplotypes in the FcεRIβ gene associated with asthma and its associated phenotypes such as serum IgE levels. A G/A polymorphism in intron 2, a (CA)n repeat polymorphism in intron 5, and a C/T polymorphism in 3'-UTR, encompassing a length of 8.74 Kb, were genotyped, and haplotypes were generated for unrelated patients and healthy volunteers in two independent cohorts. A significant association was observed at the level of alleles and genotypes studied with asthma independently in the two cohorts (p < 0.05). A change in CC_AA genotype combination to a non-CC_AA genotype was associated with reduced risk for asthma. Interestingly, a three-locus haplotype, A_16_C, was found to be significantly associated with asthma (p = 10−5 in cohort A and p = 0.004 in cohort B). On the other hand, the haplotype G_18_T was found to be negatively associated with asthma (p = 0.007 in cohort A and p = 0.0004 in cohort B). This is the first study identifying a haplotype A_16_C that predisposes individuals to asthma in the Indian population.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons. |
Keywords: | Asthma; Case-control Design; Chromosome 11q13; FcεRIβ; Genetic Association Studies; Haplotypes; Indian Population; Serum IgE; SNPs |
ID Code: | 69350 |
Deposited On: | 09 Nov 2011 08:23 |
Last Modified: | 26 Mar 2012 11:21 |
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