D'Souza, J. S. ; Dharmadhikari, J. A. ; Dharmadhikari, A. K. ; Rao, B. J. ; Mathur, D. (2011) Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: strand breakages induced by in situ electrons and radicals Physical Review Letters, 106 (11). 118101_1-118101_4. ISSN 0031-9007
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Official URL: http://prl.aps.org/abstract/PRL/v106/i11/e118101
Related URL: http://dx.doi.org/10.1103/PhysRevLett.106.118101
Abstract
Single strand breaks are induced in DNA plasmids, pBR322 and pUC19, in aqueous media exposed to strong fields generated using ultrashort laser pulses (820 nm wavelength, 45 fs pulse duration, 1 kHz repetition rate) at intensities of 1-12 TW cm-2. The strong fields generate, in situ, electrons and radicals that induce transformation of supercoiled DNA into relaxed DNA, the extent of which is quantified. Introduction of electron and radical scavengers inhibits DNA damage; results indicate that OH radicals are the primary (but not sole) cause of DNA damage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to The American Physical Society. |
| ID Code: | 69058 |
| Deposited On: | 08 Nov 2011 04:35 |
| Last Modified: | 18 Jun 2012 10:03 |
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