Das, G. ; Vohra, H. ; Saha, B. ; Mishra, G. C. (2000) Th1-specific bystander costimulation imparts resistance against mycobacterium tuberculosis infection Scandinavian Journal of Immunology, 52 (5). pp. 515-518. ISSN 0300-9475
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Official URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-...
Related URL: http://dx.doi.org/10.1046/j.1365-3083.2000.00808.x
Abstract
The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| ID Code: | 68799 |
| Deposited On: | 07 Nov 2011 04:31 |
| Last Modified: | 07 Nov 2011 04:31 |
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