Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Das, G. ; Vohra, H. ; Saha, B. ; Agrewala, J. N. ; Mishra, G. C. (1999) Apoptosis of Th1-like cells in experimental tuberculosis (TB) Clinical and Experimental Immunology, 115 (2). pp. 324-328. ISSN 0009-9104

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Official URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-...

Related URL: http://dx.doi.org/10.1046/j.1365-2249.1999.00755.x


Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-γ ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Apoptosis; Tuberculosis; Th1 Cells; Fas; Bcl-2
ID Code:68788
Deposited On:07 Nov 2011 04:31
Last Modified:07 Nov 2011 04:31

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