A convenient synthesis of 3,5,7-trihydroxy-8-methoxy flavone, prudomestin and limocitrin

Krishnamurti, M. ; Seshadri, T. R. ; Shankaran, P. R. (1966) A convenient synthesis of 3,5,7-trihydroxy-8-methoxy flavone, prudomestin and limocitrin Tetrahedron, 22 (3). pp. 941-948. ISSN 0040-4020

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0040-4020(66)80068-6

Abstract

The selective demethylation of the 5-methoxyl group of 3-hydroxy-5,8-dimethoxyflavone derivatives could not be carried out by known methods. The synthesis of 8-methoxy compounds has been achieved indirectly by the application of oxidative demethylation using nitric acid. This technique yielded 3,5,7-trihydroxy-8-methoxyflavone, prudomestin (3,5,7-trihydroxy-8,4'-dimethoxyflavone) and limocitrin (3,5,7,4'-tetrahydroxy-8,3'-dimethoxyflavone).

Item Type:Article
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ID Code:68143
Deposited On:02 Nov 2011 11:27
Last Modified:02 Nov 2011 11:27

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