Chaturvedi, Umesh C. ; Nagar, Rachna (2009) Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance? FEMS Immunology & Medical Microbiology, 56 (1). pp. 9-24. ISSN 0928-8244
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-695X.2009.00544.x
Abstract
Advances in free radical research show that reactive oxygen and nitrogen oxide species, for example superoxide, nitric oxide (NO) and peroxynitrite, play an important role in the pathogenesis of different viral infections, including dengue virus. The pathogenic mechanism of dengue haemorrhagic fever (DHF) is complicated and is not clearly understood. The hallmarks of the dengue disease, the antibody-dependent enhancement, the shift from T-helper type 1 (Th1) to Th2 cytokine response and the cytokine tsunami resulting in vascular leakage can now be explained much better with the knowledge gained about NO and peroxynitrite. This paper makes an effort to present a synthesis of the current opinions to explain the pathogenesis of DHF/shock syndrome with NO on centre stage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Microbiological Societies. |
| Keywords: | Dengue Virus; Dengue Haemorrhagic Fever; Pathogenesis; Nitric Oxide; Peroxynitrite |
| ID Code: | 6811 |
| Deposited On: | 26 Oct 2010 05:29 |
| Last Modified: | 28 May 2011 06:53 |
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