Balasubramanian, D. ; Mohan Rao, Ch. ; Panijpan, B. (1984) The malaria parasite monitored by photoacoustic spectroscopy Science, 223 (4638). pp. 828-830. ISSN 0036-8075
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Official URL: http://www.sciencemag.org/content/223/4638/828.sho...
Related URL: http://dx.doi.org/10.1126/science.6695185
Abstract
Noninvasive photoacoustic spectroscopy was used to study the malaria parasites Plasmodium chabaudi and Plasmodium berghei, their pigment, and ferriprotoporphyrin IX, which is a by-product of the hemoglobin that the parasite ingests. The results indicate that the pigment consists of ferriprotophorphyrin self-aggregates and a noncovalent complex of ferriprotoporphyrin and protein. Spectra of chloroquine-treated parasites reveal in situ interaction between the drug and ferriprotoporphyrin. Chloroquine-resistant parasites, readily distinguishable by this method, appear to degrade hemoglobin only partially.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association for the Advancement of Science. |
| ID Code: | 67996 |
| Deposited On: | 02 Nov 2011 03:03 |
| Last Modified: | 02 Nov 2011 03:03 |
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