Khanna, N. ; Agnihotri, M. ; Mathur, A. ; Chaturvedi, U. C. (1991) Neutrophil chemotactic factor produced by Japanese encephalitis virus stimulated macrophages Clinical & Experimental Immunology, 86 (2). pp. 299-303. ISSN 0009-9104
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Official URL: http://www3.interscience.wiley.com/journal/1193423...
Related URL: http://dx.doi.org/10.1111/j.1365-2249.1991.tb05813.x
Abstract
The mechanism of neutrophil leucocytosis in cases of Japanese encephalitis is not known. We here report that during Japanese encephalitis virus (JEV) infection in mice the splenic macrophages secrete a chemotactic factor that attracts the neutrophils. The peak activity of macrophage derived factor (MDF) was observed on day 7 following infection. The MDF acted in a dose-dependent manner. This chemoattractant was purified by low pressure liquid chromatography and gave a single band of 10 kD on silver stained polyacrylamide gel. The MDF was found to be heat resistant and sensitive to prolonged incubation with proteases.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to British Society for Immunology. |
| Keywords: | Japanese Encephalitis Virus; Neutrophil Chemotactic Factor Macrophage Derived Cytokine; Neutrophilia |
| ID Code: | 6750 |
| Deposited On: | 22 Oct 2010 06:30 |
| Last Modified: | 16 May 2016 17:03 |
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