Target lymphoid cells for the cytotoxic factor produced in the spleen of dengue virus-infected mice

Chaturvedi, U. C. ; Mathur, K. R. ; Gulati, Ialita ; Mathur, Asha (1981) Target lymphoid cells for the cytotoxic factor produced in the spleen of dengue virus-infected mice Immunology Letters, 3 (1). pp. 13-16. ISSN 0165-2478

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016524...

Related URL: http://dx.doi.org/10.1016/0165-2478(81)90088-2

Abstract

In previous studies we have observed the production of a cytotoxic factor by the T-lymphocytes in the spleen of dengue type-2 virus-(DV) infected mice which killed normal mouse spleen cells in vitro. In the present study types of spleen cells affected in vitro by the cytotoxic factor (CF) have been investigated. It was observed that it kills most of the macrophages, one-third of T-lymphocytes and a few of the granulocytes, normoblasts and megakaryocytes. It had no effect on B-lymphocytes. The proportion of killed cells could not be significantly enhanced by retreatment of cells by additional CF. The cytotoxic activity of CF is not affected by adsorption with susceptible or non-susceptible cells. CF also kills lymphoid cells of animals of other species, viz. albino rats, rabbits, guinea pigs but had no effect on those of rooster. It had no effect on various cell cultures.

Item Type:Article
Source:Copyright of this article belongs to European Federation of Immunological Societies.
ID Code:6736
Deposited On:22 Oct 2010 06:20
Last Modified:28 May 2011 09:26

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