Characterisation of rotavirus G9 strains isolated in the UK between 1995 and 1998

Iturriza-Gómara, Miren ; Cubitt, David ; Steele, Duncan ; Green, Jonathan ; Brown, David ; Kang, Gagandeep ; Desselberger, Ulrich ; Gray, Jim (2000) Characterisation of rotavirus G9 strains isolated in the UK between 1995 and 1998 Journal of Medical Virology, 61 (4). pp. 510-517. ISSN 0146-6615

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/1096-90...

Related URL: http://dx.doi.org/10.1002/1096-9071(200008)61:4<510::AID-JMV15>3.0.CO;2-Q

Abstract

G9P[6] and G9P[8] rotavirus strains were identified during 1995/96 through the molecular epidemiological surveillance of rotavirus strains circulating in the UK between 1995 and 1998. An increase in the incidence and spread of sporadic infections with rotavirus genotype G9P[8] across the UK was detected in the two following seasons. Partial sequencing of the VP7 gene showed that all the UK strains shared a high degree of homology and were related very closely to G9 strains from the US and from symptomatic infections in India (=96% homology). The UK strains were related more distantly to the apathogenic Indian strain 116E (85-87.8% homology). Phylogenetic analysis revealed clustering of the UK strains into 3 different lineages (I to III) and into two sub-lineages within lineage I. There were correlations between VP7 sequence clustering, the P type and the geographical origin of the G9 strains. Partial sequencing of the VP4 gene showed high degree of homology (>98%) among all the P[6] strains, and the sequences obtained from the P[8] strains clustered into 2 of the 3 global lineages described for P[8] strains associated with other G types. These data suggest that G9 strains may be a recent importation into the UK, and that G9P[8] strains may have emerged through reassortment in humans between G9P[6] strains introduced recently and the more prevalent cocirculating G1, G3 and G4 strains that normally carry VP4 genes of P[8] type.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Rotavirus; Genotype; VP7; VP4; Phylogenetic Analysis
ID Code:67016
Deposited On:28 Oct 2011 11:07
Last Modified:28 Oct 2011 11:07

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