A D-amino acid editing module coupled to the translational apparatus in archaea

Dwivedi, Shweta ; Kruparani, Shobha P. ; Sankaranarayanan, Rajan (2005) A D-amino acid editing module coupled to the translational apparatus in archaea Nature Structural & Molecular Biology, 12 (6). pp. 556-557. ISSN 1545-9993

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Official URL: http://www.nature.com/nsmb/journal/v12/n6/abs/nsmb...

Related URL: http://dx.doi.org/10.1038/nsmb943

Abstract

We report the crystal structure of an archaea-specific editing domain of threonyl-tRNA synthetase that reveals a marked structural similarity to D-amino acid deacylases found in eubacteria and eukaryotes. The domain can bind D-amino acids despite a low sequence identity to other D-amino acid deacylases. These results together indicate the presence of these deacylases in all three kingdoms of life. This underlines an important role they may have played in enforcing homochirality during translation.

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