Adrenal involvement in non-Hodgkin's lymphoma: four cases and review of literature

Singh, Devinder ; Kumar, Lalit ; Sharma, Atul ; Vijayaraghavan, M. ; Thulkar, Sanjay ; Tandon, N. (2004) Adrenal involvement in non-Hodgkin's lymphoma: four cases and review of literature Leukemia and Lymphoma, 45 (4). pp. 789-794. ISSN 1042-8194

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Official URL: http://informahealthcare.com/doi/abs/10.1080/10428...

Related URL: http://dx.doi.org/10.1080/10428190310001615756

Abstract

Primary adrenal non-Hodgkin's lymphoma is very rare. We have seen 2 such cases among 241 cases of non-Hodgkin's lymphoma (0.83%) over the past 4 years. We could detect 2 more cases who had adrenal involvement, in addition to other extra nodal disease sites. Review of English literature revealed 65 cases of primary adrenal non-Hodgkin's lymphoma, most being single case reports. Salient features included-median age of 68 years (mean age of 47.25 years in our series), bilateral adrenal involvement in 60%, and predominantly diffuse large cell histology with 'B' cell immunophenotype. Adrenal insufficiency was present in two-thirds of the patients at diagnosis. Chemotherapy with or without radiotherapy is the mainstay of treatment. About half the patients respond to treatment, with median survival of 4 months. The high index of suspicion for early diagnosis and prompt treatment may improve outcome.

Item Type:Article
Source:Copyright of this article belongs to Informa plc.
Keywords:Primary Adrenal Lymphoma; Adrenal Insufficiency; Non-hodgkin's Lymphoma
ID Code:66727
Deposited On:27 Oct 2011 06:31
Last Modified:27 Oct 2011 06:31

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