Madan, Babita ; Singh, Ishwar ; Kumar, Ajit ; Prasad, Ashok K. ; Raj, Hanumantharao G. ; Parmar, Virinder S. ; Ghosh, Balaram (2002) Xanthones as inhibitors of microsomal lipid peroxidation and TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) Bioorganic and Medicinal Chemistry, 10 (11). pp. 3431-3436. ISSN 0968-0896
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0968-0896(02)00262-6
Abstract
Xanthones bearing different functionalities, namely 1-hydroxyxanthone (1), 3-hydroxyxanthone (2), 1,4-dihydroxyxanthone (3), 2,6-dihydroxyxanthone (4), 1,2-diacetoxyxanthone (5), 2,6-diacetoxyxanthone (6), 3-methoxyxanthone (7), 1,3,7-trimethoxyxanthone (8) and 1,5-dihydroxy-6-methoxyxanthone (9) were synthesised and examined for their effect on nicotinamide adenine dinucleotide phosphate (NADPH)-catalysed liver microsomal lipid peroxidation and on tumour necrosis factor-α (TNF-α) induced expression of intercellular adhesion moledule-1 (ICAM-1) on endothelial cells, with a view to establish structure-activity relationship. Hydroxy- and acetoxyxanthones showed potent inhibitory effects on NADPH-catalysed lipid peroxidation and TNF-α induced expression of ICAM-1 on endothelial cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 66063 |
| Deposited On: | 21 Oct 2011 03:29 |
| Last Modified: | 21 Oct 2011 03:29 |
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