Mabalirajan, Ulaganathan ; Kadhiravan, Tamilarasu ; Sharma, S. K. ; Banga, Amit ; Ghosh, Balaram (2005) TH(2) immune response in patients with dengue during defervescence: preliminary evidence American journal of Tropical Medicine and Hygiene, 72 (6). pp. 783-785. ISSN 0002-9637
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Official URL: http://www.ajtmh.org/content/72/6/783.short
Abstract
A shift from a TH1 to a TH2 immune response has been observed in vitro during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-γ (IFN-γ):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4-0.47 versus 1.3, 1.0-1.9; P = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; P = 0.004) in patients than in healthy controls. The intracellular IFN-γ:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; P = 0.001). These findings suggest that a TH2 immune response occurs in patients with dengue around the time of defervescence.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society of Tropical Medicine and Hygiene. |
| ID Code: | 66051 |
| Deposited On: | 21 Oct 2011 03:31 |
| Last Modified: | 21 Oct 2011 03:31 |
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