Ranganathan, Subramania ; Jayaraman, Narayanaswamy (1991) Highly efficient propane-1,3-dithiol mediated thiol-disulphide interchange: a facile and clean methodology for S-S reduction in peptides Journal of the Chemical Society, Chemical Communications (14). pp. 934-936. ISSN 0022-4936
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/1991...
Related URL: http://dx.doi.org/10.1039/C39910000934
Abstract
Propane-1,3-dithiol, at room temperature and in the absence of any promoter, neatly brings about the S-S → 2SH change, and the latter can be isolated as acrylonitrile adducts; the methodology has been tested with several substrates including c-lysozyme, insulin and oxytocin, and spontaneous imidazole promoted S-deprotection was observed in the case of Z-Cys(S-CH2CH2CN)His-OMe.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 65981 |
| Deposited On: | 20 Oct 2011 07:08 |
| Last Modified: | 15 Jul 2012 10:08 |
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