Kotha, Sambasivarao ; Halder, Somnath ; Damodharan, Lakshminarasimhan ; Pattabhi, Vasantha (2002) First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions Bioorganic & Medicinal Chemistry Letters, 12 (7). pp. 1113-1115. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0960-894X(02)00068-9
Abstract
First synthesis of a macrocylic cyclophane-based unusual α-amino acid derivative 11 by coupling of ethyl isocyanoacetate with 1,2-bis(4-bromomethylphenyl)ethane under phase-transfer catalysis (PTC) conditions. Phosphazene base such as 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) is useful to improve the yield of cyclophane derivative without high dilution conditions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 65182 |
| Deposited On: | 15 Oct 2011 11:39 |
| Last Modified: | 15 Oct 2011 11:39 |
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