Sharma, Dipali ; Radhika, S. ; Muralidhar, K. ; Dixit, Aparna (1995) 2-Mercaptopropionylglycine modulates the expression of c-jun and c-Ha-ras in regenerating rat liver Cancer Letters, 93 (2). pp. 201-205. ISSN 0304-3835
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0304-3835(95)03810-J
Abstract
Changes in the expression of two proto-oncogenes, c-jun and c-Ha-ras and their modulation by MPG were studied in regenerating rat liver. A significant increase in c-jun and c-Ha-ras mRNA levels was noted after partial hepatectomy. However, the increase in c-Ha-ras mRNA was much less when compared with c-jun mRNA levels. Metallothionein (MT-I) mRNA levels showed a gradual decrease following partial hepatectomy. However, the decrease in MT-I mRNA levels was not significant when intertime comparisons were made. MPG caused a significant reduction in the levels of c-jun and c-Ha-ras mRNA in the regenerating rat liver compared to untreated controls, but had very little effect on MT-I mRNA levels. Selective reduction in the expression of proto-oncogenes by MPG suggests that MPG may affect the cell proliferation by modulating the expression of these genes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Regenerating liver; MPG; c-jun; c-Ha-ras |
| ID Code: | 64809 |
| Deposited On: | 17 Oct 2011 03:46 |
| Last Modified: | 17 Oct 2011 03:46 |
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