Effect of sodium fluoride — on erythrocyte membrane function — with reference to metal ion transport in rabbits

Abstract

Effect of NaF on membrane function was examined with reference to metal ion transport in rabbit's erythrocytes. Activities of membranal enzymes [Na⁺ + K⁺ - ATPase & Mg⁺⁺ - ATPase], plasma enzymes [Acid and Alkaline Phosphatases] and concentrations of Ca, Mg, Na and K were estimated in erythrocyte membrane, hemolysate and plasma. A 17% decrease in Na⁺ + K⁺ - ATPase and 37% increase in Mg⁺⁺ - ATPase have been observed after fluoride ingestion. Plasma, Acid and Alkaline Phosphatases are reduced by 27% and 34% respectively. Fluoride in circulation and in erythrocyte membrane do not effect the concentration of Na and K, however, Ca and Mg are significantly altered in erythrocyte membrane, hemolysate and plasma. It is concluded that fluoride is affecting the normal erythrocyte membrane function.